Intimate and multiple bursitis relationships bursitis between diet, immune system and microbiome (gut flora) will determine if the presence of a susceptibility (frailty) in an individual gene will manifest by the expression of a chronic inflammatory disease during his life.
For a disease of chronic inflammation can be expressed, bursitis it must meet the following conditions: 1) have inherited a genetic predisposition to such disease states; 2) there must be a factor of the environment, which is often a microbial antigen, and / or food, come allow expression of the disease in question. 3) the continuous stimulation of the immune system triggers the disease (environmental factors) seems necessary to perpetuate the immune process; 4) the imbalance of intestinal flora in the presence of certain microbial factors and / or excess food (undigested) can lead to loss of integrity of the intestinal mucosa, which normally acts as a barrier against antigens of environment. bursitis Too permeable intestinal mucosa passes into the blood and lymph circulation too many molecules insufficiently digested, so too big, which for this reason are antigenic, immunogenic and therefore possibly may trigger inappropriate pro-inflammatory reactions. All these factors seem to play an essential role in the expression of chronic inflammatory diseases in people genetically predisposed to develop this type of disease.
Celiac disease bursitis is a good example of a disease of chronic inflammation because it meets all the conditions described above. In addition, it is shown that the introduction of a gluten-free bursitis diet, usually fixes (there are exceptions bursitis which will be discussed bursitis later) the problem of hyperpermeability bursitis of the small intestine and its inflammation. The gluten-free diet does not cure the disease, she puts in remission as long as this form of diet is followed. Indeed, it appears that when environmental factor is long enough on a body by a silent inflammation bursitis *, followed by the onset of a chronic illness symptomatic (pain, loss of function), sensitivity to triggers antigens remain too high for there to cure. However, putting in remission continues as the individual does not consume the food trigger.
1) The inflammatory bursitis process (specific and innate bursitis immunity or adaptive bursitis * **) is based on complex interactions between phases of pro-and anti-inflammatory. Both phases have to be continuously in equilibrium bursitis so that there is destruction of microorganisms and the injured tissue at the proinflammatory stage and tissue repair at the anti-inflammatory phase. bursitis
2) Characteristics of silent inflammation: a phase pro-inflammatory predominance can be installed on a chronic basis, following the submission at one or more tissues, antigenic molecules of microbial origin and / or food that have crossed a small intestine too permeable. This phase is pro-inflammatory chronic low intensity and it is below the threshold of pain perception. This phenomenon makes it formidable as the person feels no symptoms so it does nothing to try to heal as it is during this period, it would be easier to try to stop the inflammation. Meanwhile, silent inflammation slowly damages the tissues in question. This type of inflammation often precedes a few years and in some cases even a few decades, the occurrence of symptomatic chronic inflammation diseases.
3) When symptomatic chronic inflammation sets in, often in relation to age, as our elimination of toxic molecules systems (mainly liver and kidneys) become less efficient with age, symptomatic manifestations appear with pain and gradual loss of function.
*: Innate immunity bursitis is the most primitive part of the immune system. It is not very specific because it is the first immune system that developed during evolution. The immune system bursitis is directed against antigenic conserved sequences may play a role trigger and called patterns recognition. Innate immunity induced immediate to different stimuli such as microbes, injury, burns, and elements of the diet answers. It mainly provides games of leukocytes (white blood cells) and polymorphonuclear cells called macrophages and cytokines.
**: The specific or adaptive immunity has developed much later during evolution. It
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