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A test that can distinguish between benign and dangerous forms of prostate cancer may develop after you now understand labyrinthitis important parts of the complex genetics underlying the most common labyrinthitis form of cancer in men, prostate kræften.Forskere believe they have demonstrated what constitutes the underlying differences labyrinthitis in the dangerous metastatic labyrinthitis prostate labyrinthitis tumor that spreads to other parts of the body, and quite harmless, slow-growing prostate tumor that does not spread in the body.
It has long been a top priority to understand the mechanism behind this difference. Now consider a team of scientists at Cold Spring Harbor Laboratory in New York, that they may have found a crucial clue about how to develop such a test.
The study, published in Cancer Cell, describes the relationship between the three genes, that together determine whether a prostate cell becomes a cancer cell, and the resulting tumor will spread.
The researchers found that a gene PHLPP1, working together labyrinthitis with another gene PTEN, which is mutated labyrinthitis in about half of all prostate cancer-stricken men. Normally works both these genes as "tumor inhibitors", ie that the normally prevent cancer developing. When both of these genes is mutated, it may lead to cancer development.
A third gene, known as p53, also acts as an inhibitor of tumor growth. This gene functions as a "Fire Extinguisher" when the other two genes is down. That is, that the p53 gene preventing cancer "fire" in spreading further. However, if p53 itself is mutated, there is very great risk that metastatic cancer develops, says Professor Lloyd Trotman.
It is known that the error function in three different genes often is a characterizing feature of metastatic cancers. Therefore depicts Lloyd Trotman to a test that measures the level of activity of these three genes, together labyrinthitis determine whether the development of cancer of the prostate.
It also opens the possibility labyrinthitis of developing drugs that can affect the metabolic pathways that are controlled by these genes. Maybe you could find drugs that can replace the function of the damaged genes, and thus again establish the tumor inhibition, as these genes normally contribute.
Approximately 250,000 labyrinthitis men in the UK are living labyrinthitis with prostate cancer, but only a small fraction of these tumors will become metastatic. If the cancer labyrinthitis starts to metastasize, however, it usually leads to death. Every day 100 men in Britain to know that they have the disease labyrinthitis - and every hour on average die a man in Britain of prostate cancer.
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