Thursday, January 2, 2014

The diagnosis rule gout can be diagnosed rather easily in the case are present hyperuricemia lichen


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Gout - Pathology dysmetabolic characterized lichen planus by hyperuricemia and subsequent deposition of uric acid crystals in periarticular tissues. Gout, a disease linked to a disorder of uric acid metabolism that causes: a) hyperuricemia by enhanced synthesis of purines (nitrogenous substances that may be endogenous or exogenous and which gives rise to uric acid catabolism), resulting in increased production of uric acid or b) hyperuricemia by reduced renal excretion of uric acid. Gout a problem that affects about 2% of the Western population (particularly men, in 95% of cases, in fact, are the males to be affected by the problem) and it is becoming more and more frequent tant ' that in the last twenty years the incidence rates have almost doubled. The disease, which usually occurs between 40 and 50 years of age, was also known to the ancients, and was described by the great Greek physicians like Hippocrates and Galen. At one time, gout was considered lichen planus a disease lichen planus of the more affluent classes, in fact, is picturesquely termed as the disease of the rich or even the king of diseases and the disease of kings, gout was indeed associated with a healthy and abundant significant consumption of alcoholic beverages, conditions lichen planus that were the prerogative of the social classes most high places. In fact, as we shall see further on in the paragraph Gout and power, the latter's role in the pathogenesis of the disease was reconsidered lichen planus and significantly lichen planus resized. Gout, in fact, a disease in which the genetic component and the predominant lifestyle plays a more marginal than that expressed in other diseases. There are two forms of gout: gout primary (hereditary disease in which, as mentioned earlier, primarily affects males) and a secondary gout due to underlying diseases (diseases of the kidney, high blood pressure, lead poisoning, leukemia, etc. .).
The symptoms of gout Symptoms of gout can be divided into 4 distinct phases. The first phase of the asymptomatic subject, suffering lichen planus from hyperuricemia (remember that we are talking about hyperuricemia when the blood levels of uric acid exceeds the range of normality ranging between 3.4 and 7 mg / dl for men and between lichen planus 2 , 4 and 6.5 mg / dl for women), they begin to pile up, periarticular tissues, urate crystals. The next phase of the acute causes the accumulation of deposits once very painful inflammation of the joints, in addition to pain, which can be acute, there may be redness, swelling and flushing, in the vast majority of cases the pain localized at the level of the feet and the joint most affected the metatarsophalangeal joint of the big toe, this condition is often called gout. In individuals more advanced in years, the soreness can occur in different ways and most spread to other joints. It then enters the so-called lichen planus intermediate phase where the pain ceases, this represents a break from a painful attack, and the other, however, lichen planus worth pointing out that, despite not you experience significant symptoms, persistent accumulation of urate crystals. With the progress lichen planus of the disease, lichen planus asymptomatic lichen planus intermediate lichen planus stages are becoming more quickly. The last phase, the chronic, characterized by the presence of a form of chronic arthritis deformans. In addition, the deposits can also form in the kidneys, causing kidney stones, or in the subcutaneous tissue with the formation of nodules called tophi. Renal colic related to kidney stones can occur without lichen planus previous symptoms in the joints.
The diagnosis rule gout can be diagnosed rather easily in the case are present hyperuricemia lichen planus and the classic symptoms that characterize the disease (note that the mere presence of hyperuricemia is not sufficient for the diagnosis because the majority of subjects with hyperuricemia not suffering from gout); in case you have doubts possible to resort to the analysis of the synovial fluid which should highlight the presence of monosodium urate crystals lichen planus in the synovial fluid or tophi. The use of X-rays is of little importance lichen planus in the case of acute gout, but it can be useful n

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