Sunday, September 22, 2013

September 2013 LMXJVSD

Dream Group AEPap "Sleep disordered breathing cancer du foie and C-reactive protein in obese children and adolescents
Van Eyck A, Van Hoorenbeeck K, De Winter BY, Ramet J, Van Gaal L, De Backer W, Verhulst SL. Sleep-disordered breathing and C-reactive protein in obese children and adolescents. Sleep Breath. 2013 Sep 3. [Epub ahead of print]
Target. Sleep-disordered breathing (SDB) are common among overweight and obese children. Is a risk factor for several health complications, including cardiovascular disease. Inflammatory processes leading to endothelial dysfunction is a possible mechanism linking SDB and cardiovascular disease. The elevation of C-reactive protein (CRP) is a risk factor for cardiovascular disease and independently correlated with the syndrome of obstructive sleep apnea (OSA) in adults. The aim of this study was to evaluate the relationship between CRP and OSAS in children and adolescents with overweight and obesity. Material and methods. One hundred and twenty children were studied prospectively (85 without OSA, 20 with mild OSA, 15 with moderate to severe OSA). All subjects underwent polysomnography, and a blood sample was taken to determine the levels of CRP. Results. No significant differences in CRP between subjects with and without OSA, and found no correlation between CRP and the severity of OSA, although the relationship between CRP and BMI (r = 0.21, p = 0.015) and between CRP and fat mass (r = 0.31, p <0.001). Conclusions. These results suggest that CRP levels correlate with the level of obesity, but are not influenced by the TRS in obese children and adolescents, in contrast to what occurs in the adult population.
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